Chia Seed Oil Prevents High Fat Diet Induced Hyperlipidemia and Oxidative Stress in Mice

Hyperlipidemia is a common cardiovascular disease. At present, the influence of high fat diet (HFD) on this is being explored. Recently, vegetable oils rich in omega‐3 have been reported that can treat hyperlipidemia caused by HFD. However, the effects of chia seed oil (CSO) on HFD‐induced hyperlipidemia and oxidative stress are poorly studied. Hence, in this study, the effects of CSO on hyperlipidemia and oxidative stress induced by HFD in mice are analyzed by various commercial kits, section staining, and protein expression. The results show that CSO decreases body weight and organ index. Meanwhile, CSO reduces serum lipid levels of total cholesterol, triglyceride, and low‐density lipoprotein cholesterol. It can also elevate superoxide dismutase and glutathione peroxidase activities and reduce malondialdehyde content in serum and liver. The results of histopathological analysis prove that CSO improves hepatic steatosis and reduces lipid deposition. Further, the results of western blot demonstrate that CSO upregulates the expression of peroxisome proliferator‐activated receptor alpha and carnitine palmitoyltransferase 1a in the liver. As a result, CSO may be a potential lipid‐lowering oil to prevent and treat HFD‐induced hyperlipidemia and oxidative stress. Practical Applications CSO, as a byproduct of chia seed processing, is a rich source of α‐linolenic acid. This study investigates the effects of CSO on HFD‐induced hyperlipidemia and oxidative stress in mice. It is concluded that dietary CSO can improve the hyperlipidemia in HFD‐induced mice via analysis of lipid parameters, histopathology study of the liver, and lipid metabolism related genes. In addition, supplementation of CSO also can improve the oxidative stress in mice. Therefore, CSO can be used for the prevention of hyperlipidemia and oxidative stress. This research provides a theoretical basis for the comprehensive development and utilization of functional chia seed oil.     

Tribological behavior studies of chemically bonded phosphate ceramic coatings reinforced with modified multi-walled carbon nanotubes (MWCNTs)

To improve the wear resistance of the chemically bonded phosphate ceramic coatings, MWCNTs are selected as the reinforcement after the modification. The high temperature wear experiment is carried out to investigate the wear behavior of the coatings with different temperatures. The results suggest that, when the temperature is below 500℃, MWCNTs can decrease friction coefficient, and the lowest friction coefficient is about 0.28, but MWCNTs lose the lubricant function at 500℃ and the friction coefficient keeps at the level of ~ 0.68. In addition, the wear resistance of coatings is improved with the introduction of MWCNTs at 100℃ and 300℃ (the wear rate is below 15X10^-3mm³/Nm), but keeps similar level at 500℃ (the wear rate is ~ 22 × 10⁻³mm³/Nm). Besides, the wear mechanism of the coatings reinforced by MWCNTs is also investigated based on the wear behavior and microstructural characterizations. MWCNTs improve the fracture toughness by preventing the crack generation and forming the bridge when crack occurs, which leads to smooth wear tracks and good wear resistance of coatings. The coatings with MWCNTs achieve poor wear resistance at 500℃ because MWCNTs lose their strength and resistance to fatigue by oxidizing.     

氮含量对HPD-1双相不锈钢组织及力学性能的影响

通过显微组织观察与力学性能测试研究了氮含量(0.08%~0.22％,质量分数)对HPD-1双相不锈钢硬度、拉伸性能、低温冲击性能及疲劳性能的影响。结果表明,氮含量变化可显著影响试验钢γ/α相比例,当氮含量由0.08％升高到0.22％,γ相含量由38.1％提高至56.5％。α相的硬度由273 HV10提高到343 HV10,γ相的硬度由238 HV10提高到299 HV10,试验钢强度明显提升。氮元素对两相比例和奥氏体相韧性的双重影响导致试验钢低温冲击性能呈先上升后下降的趋势;更高的氮含量抑制疲劳裂纹萌生与拓展,是影响HPD-1双相不锈钢室温疲劳性能的主要因素。撕裂棱是疲劳断口的显著特征。     

Discovery of New Antiproliferative Imidazopyrazole Acylhydrazones Able To Interact with Microtubule Systems

Even though immunotherapy has radically changed the search for anticancer therapies, there are still many different pathways that are open to intervention with traditional small molecules. To expand our investigation in the anticancer field, we report here a new series of compounds in which our previous pyrazole and imidazopyrazole scaffolds are linked to a differently decorated phenyl ring through an acylhydrazone linker. Preliminary tests on the library were performed at the National Cancer Institute (USA) against the full NCI 60 cell panel. The best compounds among the imidazopyrazole series were then tested by immunofluorescence staining for their inhibition of cell proliferation, apoptosis induction, and their effect on the cell cycle and on microtubules. Two compounds, in particular 4-benzyloxy-3-methoxybenzyliden imidazopyrazole-7-carbohydrazide showed good growth inhibition, with IC₅₀ values in the low-micromolar range, and induced apoptosis. Both compounds altered the cell-cycle phases with the appearance of polyploid cells. Immunofluorescence analysis evidenced microtubules alterations; tubulin polymerization assays and docking studies suggested the tubulin system to be the possible, although not exclusive, target of the new acylhydrazone series reported here.     

高地压严重突出区域下向穿层钻孔预抽消突技术

利用工作面高抽巷施工掩护顺槽掘进工作面下向穿层条带预抽钻孔,通过对钻场底板深、浅孔注浆封堵围岩裂隙解决了孔内返水不畅难题;采取了"两堵一注"封孔方式确保封孔严密不漏气;孔内全程下吹水管,实现了单孔、分组、定时吹水工作目标,提高了下向消突钻孔抽采效果,形成了一套高效、快速的下向穿层钻孔消突管理模式,实现了高地压严重突出区域煤层高效消突以及技术经济一体化目标,安全经济效益显著。     

车用有机朗肯循环系统中计量泵的性能研究

在模拟车用有机朗肯循环(organic Rankine cycle,ORC)系统的工作环境下,设计并搭建以R123作为工质的液压隔膜计量泵性能测试平台。在额定转速(2900 r/min)下,通过调节液压隔膜计量泵的冲程(25%、50%、75%、100%)和出口压力,得到变工况下液压隔膜计量泵的特性曲线,并分析液压隔膜计量泵的关键参数对车用ORC系统性能的影响情况。结果表明:液压隔膜计量泵的流量受冲程影响,与出口压力基本无关。其输入功率和实际运行效率均随着冲程的增加而升高,最高分别可达523.91 W、88.27%。应用该液压隔膜计量泵的模拟车用ORC系统吸热量变化范围较广,系统热效率最高可达12.81%。液压隔膜计量泵可应用于车用ORC系统,通过调节液压隔膜计量泵的冲程和出口压力,可实现提高车用ORC系统热效率、增加系统净输出功率的目的。     

车辆高速避让路径跟踪控制策略

建立车辆动力学模型,研究车辆在高速避让工况下的路径跟踪控制策略。基于自抗扰控制设计车辆横摆角速度以及道路曲率2种不同的路径跟踪控制器;设计基于车辆偏航位移和偏航角度加权的线性二次最优控制器;对3种控制器控制效果进行仿真验证,分析路径跟踪侧向位移误差、侧向加速度、前轮转向角以及偏航角度变化。越野车实车测试结果表明,路径跟踪控制策略正确。     

空冷器用高压水清洗与雾化降温系统集成设计与开发

高压水清洗系统和喷淋降温系统分别是春季保持空冷器翅片表面清洁和夏季保证空冷器在高温下正常运行的2个重要辅助系统。针对喷淋系统的缺点研究了高压射流雾化技术,通过试验论证了高压水清洗与雾化降温系统集成的可行性和合理性。根据设计思路开发的集成系统已在山西某项目获得应用并取得了良好的使用效果,此高压水清洗与雾化降温集成系统中高压水发生装置及介质输送管路共用,产生的高压水射流雾化颗粒可达到60μm,夏季降温效果较传统喷淋降温效果大幅提升,水资源的利用率得到极大提高,系统性价比更高。     

ASME Ⅱ卷D篇表U数据作为设计校核中材料验收标准存在问题及探讨

ASME标准钢板对于短时高温抗拉数据无规定,但设备设计人员在校核时又要用到此数据,于是有些设计文件在技术要求中将ASME II卷表U的数据作为材料验收的标准。针对此种做法引发的争议及涉及的主要问题进行试验验证和分析探讨。研究结果表明,ASME II卷D篇表U中的数据是基于室温抗拉强度保证值,并根据拟合曲线将室温保证值提高了10%得到的,实测数据与ASME规范数据不一致,部分材料在250~350℃存在动态应变时效现象,但仍不满足设计要求。材料经模拟焊后热处理后性能下降,难以到达交货态的要求。给出了短时高温抗拉强度的选用建议。     

高泉背斜地层压力测井多参数综合解释与异常高压成因

目前国内外地层压力测井解释方法较多,但大多数方法基于欠压实沉积理论并局限于单一的地层岩性,尤其是针对盆地边缘山前深层构造,单一测井参数确定地层压力误差较大,且无法解释沉积压实机制以外的异常高压。为此,将多种异常高压机制相关的测井参数进行综合解释,建立适合山前复杂构造的地层压力测井多参数计算模型,评价准噶尔盆地南缘高泉背斜高探1井的地层压力剖面,其计算结果与钻井实测数据吻合,相对误差小于3.00%.同时,基于原始沉积加载—卸载过程力学原理,利用地层压力测井多参数分析判别出高泉背斜深层各层系异常高压的形成机制。